USA patent number: 11612628
Title: New Composition for the Treatment of Articular Disorders
Year: 2023
Inventors: Mercati, Valentino, Ghelardini, Carla and Di Cesare Mannelli, Lorenzo
Abstract: The present invention relates to new compositions suitable for use in the treatment of articular disorders (or conditions), processes for preparing said compositions and use of said compositions in therapeutic treatments of articular disorders.
URL: https://patents.google.com/patent/US11612628B2/en
Australia patent number: 2025200734
Title: Epigenau/11: A Natural Matrix with Therapeutic Activity through a Physiological Network Mechanism of Action (Not Pharmacological) for Restoring Homeostasis in Tissues Infiltrated by Cancer Cells
Year: 2025
Inventors: Mercati, Valentino and Lucc, Jacopo
Abstract: The present invention relates to a 100% natural product consisting of natural matrices showing emerging properties, which allows to re-establish a correct metabolism in tissues infiltrated by cancer cells, adjuvating cancer treatment and tissue homeostasis. The product of the invention, as demonstrated by the inventors, is itself a natural matrix, representing native natural intelligence, said natural intelligence being the only capable to allow a physiological endogenous interconnection with other entities which are self-assembled in nature, such as the human species. By modulating tumor microenvironment and thus selectively inducing cancer cells mortality, the product achieves reconstitution of conditions favourable to tissue homeostasis in tissues infiltrated by cancer cells. Factually, the invention allows for a shift of paradigm based on the passage from a deterministic validation of properties to a probabilistic one based on functional redundancy logics, that will grant an industrially viable source of innovation for manufacturers in the field of 100% natural therapeutic or beneficial products.
URL: https://patents.google.com/patent/AU2025200734B1/en
Japan patent number: 7654293
Title: Method for Determining When a Natural Therapeutic or Beneficial Product Exerts Its Therapeutic or Beneficial Effect Via a Physiological Mechanism
Year: 2025
Inventors: Mercati, Valentino and Lucci, Jacopo
Abstract: The present invention relates to new methods enabling the evolution of the medical arts passing from the use of artificial substances that are chemically or biologically defined to self-assembling natural entities, obtained from natural raw materials with industrial processes that preserve the endogenous properties thereof, thereby preserving their capability to interact with the networks of the living kingdom (including humans); wherein said natural entities cannot be defined with the classical quali-quantitative composition schemes. The invention therefore provides new methods for determining when a therapeutic or beneficial product exerts its therapeutic or beneficial effect through a physiological mode of action. This method provides a necessary tool for the skilled person to assess the mechanism of action of a therapeutic or beneficial product which, with the new developments in the regulatory framework for medical devices and food supplements has become a relevant feature to assess and for which no methods are available in the art.
URL: https://www.j-platpat.inpit.go.jp/c1801/PU/JP-7654293/15/en
Japan patent number: 7616724
Title: Method for Defining Spectral Acceptance Values for Validation of One or More Test Batches of a Product for Pathological Conditions Using Spectroscopic Analysis
Year: 2025
Inventors: Mercati, Valentino and Lucci, Jacopo
Abstract: The present invention relates to a new method for defining acceptability values of the spectroscopy or spectrophotometry spectra for the compliance validation of batches by means of spectroscopy or spectrophotometry analysis of therapeutic or beneficial products, the products comprising or consisting of one or more natural matrices. The invention also relates to a new process for the compliance validation of one or more batches of said products.
URL: https://www.j-platpat.inpit.go.jp/c1801/PU/JP-7616724/15/en
Australia patent number: 2024287156
Title: A Natural Matrix Mixture for the Treatment of Bone Fragility
Year: 2025
Inventors: Mercati, valentino and Lucci, Jacopo
Abstract: The present invention relates to a 100% natural product consisting of natural matrices showing emerging properties, which allows to re-establish a correct bone metabolism by correcting the behavior of mesenchymal stem cells and re-establishing the correct balance between the cell populations that allow bone growth or remodeling. The product of the invention, as demonstrated by the inventors, is itself a natural matrix, representing native natural intelligence, said natural intelligence being the only capable to allow a physiological endogenous interconnection with other entities which are self-assembled in nature, such as the human species. By reconstituting the correct functioning of bone metabolism, the product achieves beneficial results on a systemic scale ameliorating systemic metabolism and inflammatory status. Factually, the invention allows for a shift of paradigm based on the passage from a deterministic validation of properties to a probabilistic one based on functional redundancy logics, that will grant an industrially viable source of innovation for manufacturers in the field of 100% natural therapeutic or beneficial products.
URL: https://ipsearch.ipaustralia.gov.au/patents/2024287156
Japan patent number: 7719544
Title: A Natural Matrix Mixture for the Treatment of Bone Fragility
Year: 2025
Inventors: Mercati, Valentino and Lucci, Jacopo
Abstract: The present invention relates to a 100% natural product consisting of natural matrices showing emerging properties, which allows to re-establish a correct bone metabolism by correcting the behavior of mesenchymal stem cells and re-establishing the correct balance between the cell populations that allow bone growth or remodeling. The product of the invention, as demonstrated by the inventors, is itself a natural matrix, representing native natural intelligence, said natural intelligence being the only capable to allow a physiological endogenous interconnection with other entities which are self-assembled in nature, such as the human species. By reconstituting the correct functioning of bone metabolism, the product achieves beneficial results on a systemic scale ameliorating systemic metabolism and inflammatory status. Factually, the invention allows for a shift of paradigm based on the passage from a deterministic validation of properties to a probabilistic one based on functional redundancy logics, that will grant an industrially viable source of innovation for manufacturers in the field of 100% natural therapeutic or beneficial products.
URL: https://www.j-platpat.inpit.go.jp/c1801/PU/JP-2025-109183/11/en
Australia patent number: 2024203121
Title: Validation of Natural Matrices for Therapeutic Use on Humans, Animals and Plants on Bio-Physical Bases as an Alternative to Validation through Chemically Definable Substances Derived from Said Matrices by Isolation and/or Synthesis Processes and Also as an Alternative to Products Comprising Natural Matrices Validated on the Basis of Their Traditional Use
Year: 2025
Inventors: Mercati, Valentino and Lucci, Jacopo
Abstract: The present invention relates to a new method for defining acceptability values of the spectroscopy or spectrophotometry spectra for the compliance validation of batches by means of spectroscopy or spectrophotometry analysis of therapeutic or beneficial products, the products comprising or consisting of one or more natural matrices. The invention also relates to a new process for the compliance validation of one or more batches of said products.
URL: https://ipsearch.ipaustralia.gov.au/patents/2024203121
